Tuesday, 11 February 2014

Control by Chemoreceptors


The Control of Heart Rate
Heart rate is controlled by the autonomic nervous system.
Autonomic means self-governing, the autonomic nervous system controls the involuntary (or subconscious) workings of the internal muscles and glands.
It divides into two: 
1.       The sympathetic Nervous System
Used to help us cope with stressful situations by heightening our awareness and preparing us for activity
2.       The Parasympathetic Nervous System
In general, this inhibits effectors and slows down any activity. The parasympathetic nervous system also controls activities under normal resting conditions and its purpose is to conserve energy and to replenish the body’s reserves.
These systems are often antagonistic. If one system contracts a muscle, then the other relaxes it. Our internal glands and muscles are therefore regulated by a balance of the two systems.
One such example is heart rate:
·         The resting heart rate of an average human being is around 70 beats per minute
·         During exercise the resting heart rate may need to more than double to supply the active tissue with oxygen and food.
Changes to the heart rate are controlled by the Medulla Oblongata a region of the brain which has two centres.
1)      The first decreases heart rate- Parasympathetic Nervous System 
2)      The second that increases heart rate – Parasympathetic Nervous System
Both of these centres and linked to the Sino atrial node by their various nervous systems
The site that is stimulated depends upon the stimuli received by the receptor. In the case of heart rate it could be either
1)      Chemical changes in the blood, detected by chemoreceptors
2)      Pressure changes in the blood detected by Baroreceptors






Control by Chemoreceptors
·         Chemoreceptors detect chemical changes and are found in the walls of the carotid arteries which serve the brain.
·         These chemoreceptors are sensitive to changes in the pH of the blood that result from the changes in carbon dioxide concentration changes.
The process works as follows
1)      When pH falls the chemoreceptors in the walls of the carotid arteries and aorta detect this and increase the frequency at which they send nervous impulses to the centre in the medulla oblongata that is responsible for increasing heart rate.
2)      Via the sympathetic nervous system, the medulla oblongata in turn increases the rate at which it send nervous impulses to the Sino atrial node.
3)      The Sino atrial node as a result increases the rate at which it causes the muscles of the heart to contract.
4)      This means that the blood travels around the body faster and thus more carbon dioxide is removed from the blood by the lungs.
5)      With less carbon dioxide in the blood the pH returns to its normal value.
6)      This rise in pH is detected by the carotid arteries and they reduce the frequency at which they send impulses to the medulla oblongata causing the heart rate to return to normal.

Control by the pressure receptors
These receptors are also found in the carotid arteries and walls of the aorta.
They operate much the same as the chemoreceptors
1)      A higher than normal blood pressure is detected by the pressure receptors
2)      Nervous impulses are transmitted to the centre in the medulla oblongata
3)      The medulla oblongata in turn decreases the rate at which it sends nervous impulses to the Sino atrial node via the parasympathetic nervous system.
4)      The Sino atrial node stops the heart beating as fast or as powerful
5)      Blood pressure falls.



Monday, 20 January 2014

Translation


Translation
Translation is the process by which the information on mRNA is used by the tRNA to synthesise a polypeptide chain which will eventually form a protein. The formation of proteins happens in the ribosomes which can be situated freely in the cytoplasm or just attached/part of the rough endoplasmic reticulum. The proteins which as synthesised freely in the cytoplasm are used by the cell for its various functions, the protein synthesised by the ribosomes on the rough endoplasmic reticulum often go to the Gogli apparatus before being released by the cells into the surroundings.
The ribosomes ‘read’ the genetic message on the mRNA while the tRNA delivers the amino acids in the sequence originally determined by the template strand of the DNA.
Remember
The structure of tRNA
·         The anti-codon is complementary to the nucleotides on the mRNA strand and the acceptor strand is complementary to the relevant amino acid.

The Structure/Role
·         To pick up amino acids from the cytoplasm and to transfer them to the ribosomes in the correct sequence.
The Process
1.       The codons on the mRNA move the ribosomes from the nucleus out of the nuclear pores in the nuclear envelope.
2.       tRNA collects the complementary anti-codon triplet which is situated on the mRNA strand.
3.       The amino acid is put into the right place in the chain.
4.       The amino acid bonds to the forming polypeptide chain while the tRNA is released.
5.       The process is repeated until the whole of the mRNA chain has been translated
The correct sequence from the original DNA has been transferred and a polypeptide chain has been made.
In the Ribosomes on the rough endoplasmic reticulum after translation the proteins pass into the cisternae of the golgi. Vesicles are formed containing the proteins in a concentrated form with the possible addition of carbohydrates. The vesicles break off abd move to the cell membrane, the vesicles then fuse with the cell membrane and are carried through the membrane to be secreted into the surrounding environment.  


Wednesday, 15 January 2014

Genes and Gene Expression


Genes and Gene Expression
Ribonucleic acid  RNA
RNA unlike DNA forms a single strand in which nucleotides make up.
Each nucleotide is made of:
·         The pentose sugar ribose
·         An organic base Adenine (A) , Guanine (G) Cytosine (C) and Uracil (U)
·         A phosphate group
·         There are two types of organic bases; purines and pyrimidines.
·         Purines are made up of Hexagonal and Pentagonal rings, Adenine and Guanine are purines.
·         Pyrimidines are made up of a single Hexagonal ring and consist of Thymine, Cytosine and Uracil.
·         Remember form AS - Guanine with Cytosine and Adenine with Uracil (RNA) or Thymine (DNA)
Transcription= DNA à RNA
Translation = RNA à Protein
Therefore DNAà RNA àProtein
There are two types of RNA that are important in protein synthesis, they are
·         Messenger RNA (mRNA)
·         Transfer RNA
Important Note!
·         When we talk about a triplet code or a codon we are talking about messenger RNA
·         In RNA there is no Thymine but rather it is replaced by Uracil
Messenger RNA (mRNA)
·         mRNA is a long strand that is arranged in a single helix
·         mRNA leaves the nucleus via pores in the nuclear envelope and enters the cytoplasm where it comes into contact with the genetic code.
Transfer RNA (tRNA)
·         tRNA is a smaller molecule but is still made up of a single strand.
·         The single strand is folded into a clover-leaf shape where one end of the strand extends beyond the other.
This extended section is that which an amino acid can be attached to.
·         At the opposite end of the tRNA there is an anticodon. The anticodon is made up of three other bases.
·         For each amino acid there is a different sequence of organic bases on the anticodon.
During protein synthesis the anticodon pairs with the three complementary bases that make up the triplet bases (codon) on mRNA. The structure of tRNA means that is structurally suited to its role in lining up amino acids on the mRNA template during the protein synthesis.
·         The end chain is for attaching amino acids
·         The anticodon is for pairing with the codons of mRNA